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Asymmetric Amplification in Phosphoric Acid Catalyzed Reactions

Authors

  • Nan Li,

    1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chengdu, 610041 (China)
    2. Graduate School of Chinese Academy of Sciences, Beijing (China)
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  • Xiao-Hua Chen Dr.,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
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  • Shi-Ming Zhou,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
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  • Shi-Wei Luo Dr.,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
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  • Jin Song,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
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  • Lei Ren,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
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  • Liu-Zhu Gong Prof.

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China), Fax: (+86) 551-360-6266
    2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chengdu, 610041 (China)
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  • We are grateful for financial support from NSFC (20732006), MOST (973 program 2010CB833300), and the Ministry of Health (2009ZX09501-017).

Abstract

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Mehree! Die asymmetrische Verstärkung in Phosphorsäure-Katalysen folgt aus der Bildung schlechter löslicher, supramolekularer Strukturen (siehe Schema; O rot, P gelb, C grau, H weiß) aus den racemischen Phosphorsäuren, die darin Wasserstoffbrücken mit Kristallwasser-Molekülen bilden. Dieses Ergebnis erklärt, warum auch bei Einsatz nicht enantiomerenreiner Phosphorsäuren hoch enantioselektive Reaktionen gelingen können.

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