Total Synthesis of Dictyodendrin A and B

Authors

  • Kentaro Okano Dr.,

    1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan), Fax: (+81) 22-795-6877
    2. Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Hideto Fujiwara,

    1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan), Fax: (+81) 22-795-6877
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  • Toshiharu Noji,

    1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan), Fax: (+81) 22-795-6877
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  • Tohru Fukuyama Prof. Dr.,

    1. Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Hidetoshi Tokuyama Prof. Dr.

    1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan), Fax: (+81) 22-795-6877
    2. Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • This work was financially supported by the KAKENHI, Grant-in-Aid for Scientific Research (B; 20390003), Young Scientists (Start-up; 19890014), Young Scientists (B; 21790006), and Suntory (Sunbor Grant). The authors thank Profs. S. Matsunaga and N. Fusetani (University of Tokyo) for providing valuable information and their spectral data.

Abstract

original image

Indolin mittendrin: Eine neuartige Indolinbildung aus einem Benz-in mit direkt anschließender Kreuzkupplung führt zu dem hoch substituierten Schlüsselintermediat einer effizienten Totalsynthese von Dictyodendrin A und B. Durch Anbringen der Substituenten an das Indolinsystem in modularer Weise wurde die Totalsynthese abgeschlossen.

Ancillary