An Efficient Titanium Catalyst for Enantioselective Cyanation of Aldehydes: Cooperative Catalysis

Authors

  • Dr. Zhipeng Zhang,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China), Fax: (+86) 21-6416-6128
    Search for more papers by this author
  • Dr. Zheng Wang,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China), Fax: (+86) 21-6416-6128
    Search for more papers by this author
  • Dr. Ruzhou Zhang,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China), Fax: (+86) 21-6416-6128
    Search for more papers by this author
  • Prof. Dr. Kuiling Ding

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China), Fax: (+86) 21-6416-6128
    Search for more papers by this author

  • Financial support from the National Natural Science Foundation of China (Nos. 20632060, 20821002, 20923005), the Chinese Academy of Sciences, the Major Basic Research Development Program of China (Grant No. 2010CB833300), and the Science and Technology Commission of Shanghai Municipality is gratefully acknowledged.

Abstract

original image

Zwei in einem: Die Kombination von zwei Salen-Ti[DOUBLE BOND]O-Einheiten in einem einzigen Molekül ermöglicht die enantioselektive Cyanierung von Aldehyden zur Bildung von enantiomerenangereicherten natürlichen oder nichtnatürlichen Cyanhydrinen mit Umsatzzahlen von 1960 bis 172 000 und bis 97 % ee (siehe Schema). Einige der Cyanhydrine sind Schlüsselintermediate in der Synthese von chiralen Pharmazeutika und Agrochemikalien.

Ancillary