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Total Synthesis of (−)-Virginiamycin M2

Authors


  • Financial support was obtained from NIH CA 53604. The authors are grateful to Dr. Baptiste Ronan at Sanofi-Aventis for 1H NMR spectrum comparison of compound 22, Dr. Yun Zhang at Novartis Institute (Cambridge, MA), Dr. Jason T. Lowe at the Broad Institute (Cambridge, MA) for helpful discussions, Dr. Paul Ralifo and Dr. Norman Lee at Boston University for assistance with NMR and HRMS measurements.

Abstract

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Alles dreht sich um den Ring: In einer direkten und modularen Totalsynthese des natürlichen Antibiotikums Virginiamycin M2 schließt eine Barbier-Cyclisierung den 23-gliedrigen Makrocyclus. Von einem chiralen Organosilan aus ist Virginiamycin M2 nach 19 Stufen erreicht.

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