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An Unusual Galactofuranose Lipopolysaccharide That Ensures the Intracellular Survival of Toxin-Producing Bacteria in Their Fungal Host

Authors

  • Dr. Maria R. Leone,

    1. Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II via Cintia 4, 80126 Napoli (Italy)
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    • These authors contributed equally.

  • Dipl.-Biochem. Gerald Lackner,

    1. Abteilung für Biomolekulare Chemie, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, HKI, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
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    • These authors contributed equally.

  • Prof. Dr. Alba Silipo,

    1. Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II via Cintia 4, 80126 Napoli (Italy)
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  • Prof. Dr. Rosa Lanzetta,

    1. Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II via Cintia 4, 80126 Napoli (Italy)
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  • Prof. Dr. Antonio Molinaro,

    1. Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II via Cintia 4, 80126 Napoli (Italy)
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  • Prof. Dr. Christian Hertweck

    1. Abteilung für Biomolekulare Chemie, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, HKI, Beutenbergstrasse 11a, 07745 Jena (Germany), Fax: (+49) 3641-532-0804
    2. Friedrich-Schiller-Universität, Jena (Germany)
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  • We thank the JCVI Annotation Service for providing us with automatic annotation data and the manual annotation tool Manatee, K. Graupner for PCR screening of mutants, L. Sturiale for MS spectra, and G.-M. Schwinger for fungal-strain maintenance. This research was supported by the graduate school of excellence ILRS/JSMC (C.H.) and by PRIN MIUR 2007/2008 (R.L. and A.M.).

Abstract

original image

Dresscode für das Leben in einem Pilz: Die Analyse der Kohlenhydrathülle des toxinproduzierenden Endobakteriums des phytopathogenen Pilzes Rhizopus microsporus ergab eine neuartige Lipopolysaccharid(LPS)-Struktur, die für die Infektion und Besiedelung des Pilzwirts wesentlich ist. Eine Mutante ohne das ungewöhnliche [→2)-β-D-Galactofuranose-(1→]n-O-Antigen (im Schema rot) konnte keine stabile Symbiose mit dem Pilz eingehen.

Ancillary