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Arylation of α-Chiral Ketones by Palladium-Catalyzed Cross-Coupling Reactions of Tosylhydrazones with Aryl Halides

Authors

  • Prof. José Barluenga,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-446
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  • María Escribano,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-446
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  • Prof. Fernando Aznar,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-446
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  • Dr. Carlos Valdés

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33006 Oviedo (Spain), Fax: (+34) 985-103-446
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  • Financial support of this work from the DGI of Spain (CTQ2007-61048/BQU), the Consejería de Educación y Ciencia of Principado de Asturias (IB08-088), and a FPU predoctoral fellowship from the MCINN of Spain to M.E. is gratefully acknowledged.

Abstract

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Vollständig erhalten bleibt die Konfiguration am α-C-Atom konfigurativ instabiler α-chiraler Ketone bei der Titelreaktion. Die Regioselektivität in der β-Hydrideliminierung ist entscheidend für die Retention der Konfiguration. Boc=tert-Butoxycarbonyl, TS=Toluol-4-sulfonyl.

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