Catalytic Asymmetric Direct Henry Reaction of Ynals: Short Syntheses of (2S,3R)-(+)-Xestoaminol C and (−)-Codonopsinines

Authors

  • Dr. Daisuke Uraguchi,

    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho B2-3(611), Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3338
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  • Shinji Nakamura,

    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho B2-3(611), Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3338
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  • Prof. Dr. Takashi Ooi

    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho B2-3(611), Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3338
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  • This work was supported by grants from the JSPS for Scientific Research, the Global COE program in Chemistry of Nagoya University, and the Asahi Glass Foundation.

Abstract

original image

Drei sind ein guter Start: Eine Reihe optisch aktiver anti-β-Nitropropargylalkohole wurde durch die katalytische stereoselektive Addition von Nitroalkanen an Inale erhalten. Diese direkte Henry-Reaktion von Inalen eröffnete einen raschen Zugang zu drei Naturstoffen über Transformationen der Kohlenstoff-Kohlenstoff-Dreifachbindung.

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