Stereoselective Synthesis of α-Diazo Oxime Ethers and Their Application in the Synthesis of Highly Substituted Pyrroles through a [3+2] Cycloaddition

Authors

  • Emmanuvel Lourdusamy,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6513-2748
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  • Lin Yao,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6513-2748
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  • Prof. Dr. Cheol-Min Park

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6513-2748
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  • We gratefully acknowledge Nanyang Technological University Start Up Grant for the funding of this research. We thank Dr. Yongxin Li for X-ray crystallographic analysis. We also thank Prof. Sunggak Kim for careful reading of the manuscript.

Abstract

original image

3+2=Pyrrol: Der stereoselektive Diazotransfer mit Oximethern eröffnet einen effizienten Zugang zu den jeweiligen α-Diazooximethern. Die Nützlichkeit dieser Verbindungen wurde durch die Synthese hoch substituierter Pyrrole über eine [3+2]-Cycloaddition von α-Oximinocarbenoiden mit Enaminen demonstriert (siehe Schema).

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