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Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release

Authors

  • Dr. Sang-Min Lee,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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    • These authors contributed equally to this work.

  • Dr. Ying Song,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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    • These authors contributed equally to this work.

  • Dr. Bong Jin Hong,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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    • These authors contributed equally to this work.

  • Dr. Keith W. MacRenaris,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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    • These authors contributed equally to this work.

  • Daniel J. Mastarone,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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  • Prof. Thomas V. O'Halloran,

    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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  • Prof. Thomas J. Meade,

    Corresponding author
    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
    • Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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  • Prof. SonBinh T. Nguyen

    Corresponding author
    1. Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
    • Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
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  • This work is financially supported by the NIH (NCI Center of Cancer Nanotechnology Excellence Grant U54 A119341 and Core Grant P30 A060553 to the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and award number R01EB005866 from the National Institutes of Biomedical Imaging and Bioengineering). B.J.H. is partially supported by the National Research Foundation of Korea (NRF-2009-352-C00088).

Abstract

original image

Polymerverkapselte Nanobehälter (PCNs), die zu Kupfer(I)-katalysierten Klick-Reaktionen fähig sind, ermöglichen die Kombination von Gadolinium(III)-Kontrastmitteln für die Kernspintomographie mit dem Cytostatikum Gemcitabin (GMC) in einer theranostischen Plattform (siehe Bild). Die mit Gadolinium(III) verknüpften und mit GMC beladenen PCNs (GdIII–PCNGMC) zeigen deutlich verbesserte Ergebnisse bezüglich der r1-Relaxivitäten, der Wirkstoffaufnahme und der pH-empfindlichen Wirkstoff-Freisetzung.

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