Cross-Dehydrogenative Coupling Reactions by Transition-Metal and Aminocatalysis for the Synthesis of Amino Acid Derivatives

Authors

  • Jin Xie,

    1. Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China)
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  • Prof. Zhi-Zhen Huang

    Corresponding author
    1. Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China)
    2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (P. R. China)
    • Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China)
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  • Financial support from the National Natural Science Foundation of China (No. 20872059 and 21072091) and MOST of China (973 program, 2011CB808600) are gratefully acknowledged. We also thank Prof. Chao-Jun Li, McGill University, for helpful discussions.

Abstract

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Direkter Weg: Die Titelreaktionen von N-Arylglycinestern mit nichtmodifizierten Ketonen verlaufen in Gegenwart von tert-Butylhydroperoxid (TBHP) oder 2,3-Dichlor-5,6-dicyan-1,4-benzochinon (DDQ) glatt und unter milden Bedingungen (siehe Schema). Das zur C-H-Aktivierung eingesetzte Oxidationsmittel bestimmt die Selektivität der Reaktionen für einen bestimmten Typ von Ketonsubstrat.

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