Get access
Advertisement

Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles

Authors

  • Dr. Bo Han,

    1. Key laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 288-550-2609
    Search for more papers by this author
  • You-Cai Xiao,

    1. Key laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 288-550-2609
    Search for more papers by this author
  • Yuan Yao,

    1. Key laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 288-550-2609
    Search for more papers by this author
  • Prof. Dr. Ying-Chun Chen

    Corresponding author
    1. Key laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 288-550-2609
    2. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041(China)
    • Key laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (China), Fax: (+86) 288-550-2609
    Search for more papers by this author

  • We are grateful for financial support from the NSFC (20972101 and 21021001) and the National Basic Research Program of China (973 Program; grant no. 2010CB833300).

Abstract

original image

Anellierung von Heterocyclen: Die direkte Enamin-Imin-Isomerisierung von Indolen unter Lewis-Säure-Katalyse, eine einzigartige intramolekulare Imino-En-Reaktion, gelingt bei Indolen mit einer Olefineinheit in der Seitenkette und liefert anellierte Indolinheterocyclen mit ausgezeichneter Diastereokontrolle (siehe Schema).

Get access to the full text of this article

Ancillary