Direct Synthesis of Water-Tolerant Alkyl Indium Reagents and Their Application in Palladium-Catalyzed Couplings with Aryl Halides

Authors

  • Zhi-Liang Shen,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Kelvin Kau Kiat Goh,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Yong-Sheng Yang,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Yin-Chang Lai,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Colin Hong An Wong,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Hao-Lun Cheong,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Prof. Dr. Teck-Peng Loh

    Corresponding author
    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
    • Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • We gratefully acknowledge Nanyang Technological University (NTU), the Ministry of Education (No. M45110000), and A*STAR SERC Grant (No. 0721010024) for the funding of this research.

Abstract

original image

Durch CuCl-vermittelte Insertion von Indium in Alkylhalogenide wurden Alkylindiumreagentien erzeugt und unter Palladiumkatalyse mit Arylhalogeniden gekuppelt (siehe Schema). Die Reagentien sind mit verschiedenen funktionellen Gruppen verträglich und daher von allgemeinem Nutzen für organische Synthesen. DMA=N,N-Dimethylacetamid, TBS=tert-Butyldimethylsilyl.

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