Franklinolides A–C from an Australian Marine Sponge Complex: Phosphodiesters Strongly Enhance Polyketide Cytotoxicity

Authors

  • Dr. Hua Zhang,

    1. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072 (Australia), Fax: (+61) 7-3346-2090
    Search for more papers by this author
  • Melissa M. Conte,

    1. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072 (Australia), Fax: (+61) 7-3346-2090
    Search for more papers by this author
  • Prof. Robert J. Capon

    Corresponding author
    1. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072 (Australia), Fax: (+61) 7-3346-2090
    • Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072 (Australia), Fax: (+61) 7-3346-2090
    Search for more papers by this author

  • We thank CSIRO Marine Research and the crew of the RV Franklin for assistance in sponge collection, L. Goudie (Museum Victoria) for sponge taxonomy, C. Cuevas and colleagues (PharmaMar) for preliminary in vitro anticancer screening, and A. M. Piggott (UQ) for the acquisition of HRESI(±)MS data. This work was funded partially by the Australian Research Council, with additional support from PharmaMar (Madrid, Spain).

Abstract

original image

Seltene Entdeckung: Drei neuartige Polyketidphosphodiester, die Franklinolide A–C, wurde als die zytotoxischen Komponenten eines australischen Meeresschwamms identifiziert. Struktur-Aktivitäts-Studien auf der Basis von In-vitro-Zytotoxizitäts- und Zellproliferationstests ergaben, dass die Einführung der Phosphodiestergruppe die Zytotoxizität um das 30- bis über 300-fache erhöht.

Ancillary