Laser-Induced Cell Detachment and Patterning with Photodegradable Polymer Substrates

Authors

  • Dr. George Pasparakis,

    Corresponding author
    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    • Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
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  • Theodore Manouras,

    1. Institute of Microelectronics, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki (Greece)
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  • Dr. Alexandros Selimis,

    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
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  • Dr. Maria Vamvakaki,

    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology—Hellas (FORTH), P.O. Box 1527, 71110 Heraklion, Crete (Greece), Fax: (+30) 2810-391-305
    2. Department of Materials Science and Technology, University of Crete, 71003 Heraklion, Crete (Greece)
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  • Dr. Panagiotis Argitis

    1. Institute of Microelectronics, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki (Greece)
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  • We gratefully acknowledge Thomas Papastathis for his help with the chamber design and Apostolos Englezis for his advice on the laser optics and setup.

Abstract

original image

Schon durch Photolyse mit niedrigen Energien werden die Hauptketten von Polymeren gespalten, die zu effizienten Substraten für die sichere Abtrennung und Musterbildung von Zellen mithilfe von Laserlicht entwickelt wurden. Die Polymere, die neben Acetal- oder Ketaleinheiten auch absorbierende Gruppen im Rückgrat enthalten, zersetzen sich bei der Bestrahlung mit einem Excimer-Laser schnell, wodurch lebende Zellen freigesetzt werden konnten (siehe Bild).

Ancillary