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Cyclization–Carbonylation–Cyclization Coupling Reactions of Propargyl Acetates and Amides with Palladium(II)–Bisoxazoline Catalysts

Authors

  • Sumie Yasuhara,

    1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan), Fax: (+81) 474-721-825
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  • Makiko Sasa,

    1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan), Fax: (+81) 474-721-825
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  • Dr. Taichi Kusakabe,

    1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan), Fax: (+81) 474-721-825
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  • Dr. Hiroyuki Takayama,

    1. School of Pharmacy, Nihon Pharmaceutical University, 10281, Komuro, Inamachi, Kita-Adachigun, Saitama (Japan)
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  • Prof. Dr. Masayuki Kimura,

    1. School of Pharmacy, Nihon Pharmaceutical University, 10281, Komuro, Inamachi, Kita-Adachigun, Saitama (Japan)
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  • Prof. Dr. Tomoyuki Mochida,

    1. Department of Chemistry, Faculty of Sciences, Kobe University, Rokkodai, Nada, Kobe 657-8501 (Japan)
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  • Prof. Dr. Keisuke Kato

    Corresponding author
    1. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan), Fax: (+81) 474-721-825
    • Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan), Fax: (+81) 474-721-825===

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Abstract

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Die Titelreaktionssequenz mit Propargylacetaten 1 oder -amiden 2 in Gegenwart eines Palladium(II)-Bisoxazolin(box)-Katalysators lieferte symmetrische Ketone vom Typ 3 und 4 mit zwei heterocyclischen Einheiten in mäßigen bis ausgezeichneten Ausbeuten (siehe Schema; tfa=Trifluoracetat). Die Verbindungen 3 wurden in Ketone mit zwei 3(2H)-Furanonringen überführt.

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