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Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh–Cu Bimetallic Cooperation

Authors

  • Yi-Feng Wang,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Kah Kah Toh,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Jian-Yuan Lee,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • Dr. Shunsuke Chiba

    Corresponding author
    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
    • Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore), Fax: (+65) 6791-1961
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  • This work was supported by funding from Nanyang Technological University and Singapore Ministry of Education (Academic Research Fund Tier 2: MOE2010-T2-1-009).

Abstract

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Katalysatoren als Partner: Im Schema ist ein neues Verfahren zur Synthese hoch substituierter Isochinoline illustriert (Cp*=C5Me5, DMF=N,N-Dimethylformamid, TEMPO=2,2,6,6-Tetramethylpiperidin-1-oxyl). Aus ersten mechanistischen Untersuchungen lässt sich folgern, dass Rhodium und Kupfer in der Mehrstufensequenz synergistisch kooperieren.

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