Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide

Authors

  • Dr. Shigeru Matsuoka,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
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  • Dr. Naoki Shinohara,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
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  • Tomoaki Takahashi,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
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  • Maiko Iida,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
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  • Prof. Dr. Masayuki Inoue

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
    • Graduate School of Pharmaceutical Sciences, The University of Tokyo and PRESTO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-3395-5214
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  • This work was supported financially by the Funding Program for Next Generation World-Leading Researchers (JSPS), Grant-in-Aid for Young Scientists (S) (JSPS), the Takeda Science Foundation, and the Naito Foundation. The fellowship for N.S. from JSPS is gratefully acknowledged.

Abstract

original image

Länger ist besser: Polytheonamid B, das bislang größte identifizierte nichtribosomale lineare Peptid, ist ein kanalbildendes Transmembranpeptid. Neun seiner Unterstrukturen wurden nun chemisch synthetisiert. Die membranzerstörende und die ionenkanalbildende Sequenz sowie die die Cytotoxizität verstärkende Sequenz wurden identifiziert.

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