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Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

Authors

  • Dr. Jinjun Shi,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
    2. MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
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  • Dr. Zeyu Xiao,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
    2. MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
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  • Alexander R. Votruba,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
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  • Dr. Cristian Vilos,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
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  • Prof. Omid C. Farokhzad

    Corresponding author
    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
    2. MIT–Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
    • Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
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  • This work was supported by National Institutes of Health (NIH) grants CA151884, EB003647, and N01 HV-08236, and the David Koch—Prostate Cancer Foundation Award in Nanotherapeutics. We also thank Dr. Akin Akinc (Alnylam Pharmaceuticals, Inc.) and Prof. Daniel G. Anderson (MIT) for providing Dual–Luc HeLa cells and GFP–HeLa cells.

Abstract

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Schnellzustellung: Biologisch abbaubare und verträgliche Polymere und Lipide bilden Kern-Schale-Hybridnanopartikel (links im Bild) für den Transport von siRNA in vitro wie in vivo. Die einzigartige Lipid-Polymer-Lipid-Nanostruktur, die dem Transportsystem seine bemerkenswerten Funktionen verleiht, wurde elektronen- und fluoreszenzmikroskopisch charakterisiert (rechts).

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