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Cell-Penetrating Homochiral Cyclic Peptides as Nuclear-Targeting Molecular Transporters

Authors

  • Dr. Deendayal Mandal,

    1. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881 (USA)
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  • Amir Nasrolahi Shirazi,

    1. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881 (USA)
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  • Prof. Keykavous Parang

    Corresponding author
    1. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881 (USA)
    • Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881 (USA)
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  • We acknowledge financial support from the National Science Foundation, grant number CHE 0748555, and the American Cancer Society grant number RSG-07-290-01-CDD.

Abstract

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Amphipathische cyclische L-Peptide erleichtern die Aufnahme von fluoreszenzmarkiertem Lamivudin und einem Phosphopeptid in Zellen. Das entsprechende fluoreszenzmarkierte Konjugat F-[W5R4K] wurde hoch effizient in den Kern von Darmadenokarzinom-, Brustkarzinom- und Ovarialadenokarzinom-Zellen transloziert (siehe Bild).

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