Photosensitizing Hollow Nanocapsules for Combination Cancer Therapy

Authors

  • Kyung Jin Son,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-Gu, Seoul 120-749 (Korea)
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    • These authors contributed equally to this work.

  • Hee-Jae Yoon,

    1. Department of Chemistry, Yonsei University, 50 Yonsei-ro,Seodaemoon-Gu, Seoul 120-749 (Korea)
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    • These authors contributed equally to this work.

  • Joo-Ho Kim,

    1. Department of Chemistry, Yonsei University, 50 Yonsei-ro,Seodaemoon-Gu, Seoul 120-749 (Korea)
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  • Prof. Woo-Dong Jang,

    Corresponding author
    1. Department of Chemistry, Yonsei University, 50 Yonsei-ro,Seodaemoon-Gu, Seoul 120-749 (Korea)
    • Department of Chemistry, Yonsei University, 50 Yonsei-ro,Seodaemoon-Gu, Seoul 120-749 (Korea)
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  • Yeol Lee,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-Gu, Seoul 120-749 (Korea)
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  • Prof. Won-Gun Koh

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-Gu, Seoul 120-749 (Korea)
    • Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-Gu, Seoul 120-749 (Korea)
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  • This work was supported by the National Research Foundation (NRF) grant funded by the Korean government (R11-2007-050-03002-0: Active Polymer Center for Pattern Integration, 2011-0001126: Center for Bioactive Molecular Hybrids, and 20100019175) and the KRIBB Research Initiative Program. K.J.S., H.-J.Y., J.K., and Y.L. acknowledge fellowships form the BK21 program from MEST, Korea.

Abstract

original image

Vielschichtig und lichtempfänglich: Die schichtweise selbstorganisierte Abscheidung eines dendritischen Porphyrins (rot) und von Poly(allylamin-hydrochlorid) (blau) auf Polystyrolnanopartikeln und anschließendes Entfernen des Polystyrolkerns führen zu multifunktionellen hohlen Nanokapseln, die sowohl mit Tumortherapeutika beladen als auch in der photodynamischen Therapie verwendet werden können.

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