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Programming the Cellular Uptake of Physiologically Stable Peptide–Gold Nanoparticle Hybrids with Single Amino Acids

Authors

  • Dr. Hong Yang,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, M5G 1L7 (Canada)
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  • Dr. Shan-Yu Fung,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, M5G 1L7 (Canada)
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  • Prof. Mingyao Liu

    Corresponding author
    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, M5G 1L7 (Canada)
    2. Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5G 2C4 (Canada)
    • Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, M5G 1L7 (Canada)
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  • We thank Steven Doyle, Battista Calvieri, and Yan Chen at the TEM facility center for technical assistance in cell embedding and TEM imaging. We acknowledge Prof. Gang Zheng for allowing the use of the instrument to conduct UV/Vis, DLS, and zeta potential experiments. We also thank Prof. Vladimir Baranov and Leslie Fung for help with ICP-MS measurements. We thank Feng Xu for help with confocal microscopy. S.Y.F. would like to acknowledge the Ontario Ministry of Research and Innovation and Michael V. Plachta and Wanda Plachta for providing a fellowship. The financial support of this project was from the Canadian Institutes of Health Research (MOP-13270 and MOP-42546).

Abstract

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Die Aufnahme von Gold-Nanopartikeln durch Krebszellen kann über die Art der Hexapeptidliganden an der Partikeloberfläche gezielt manipuliert werden. Bereits 5 % eines Tryptophan- oder Serin-terminierten Peptids in der Ligandenmischung genügen, um eine solche Feinabstimmung herbeizuführen. Die Partikelaufnahme wird durch die Struktur des aromatischen Rings an der terminalen Aminosäure bestimmt, nicht etwa durch ihre Hydrophobie.

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