Zuschrift

Synthesis of Oximidine II by a Copper-Mediated Reductive Ene–Yne Macrocyclization†

  1. Dr. Christopher M. Schneider2,
  2. Dr. Kriangsak Khownium2,
  3. Wei Li3,
  4. Dr. Jared T. Spletstoser2,
  5. Dr. Torsten Haack2,
  6. Dr. Gunda I. Georg1,*

Article first published online: 29 JUN 2011

DOI: 10.1002/ange.201103081

Issue

Angewandte Chemie

Angewandte Chemie

Volume 123, Issue 34, pages 8001–8003, August 16, 2011

Additional Information

How to Cite

Schneider, C. M., Khownium, K., Li, W., Spletstoser, J. T., Haack, T. and Georg, G. I. (2011), Synthesis of Oximidine II by a Copper-Mediated Reductive Ene–Yne Macrocyclization. Angew. Chem., 123: 8001–8003. doi: 10.1002/ange.201103081

Author Information

  1. 1

    Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414 (USA)

  2. 2

    Department of Medicinal Chemistry, University of Kansas (USA)

  3. 3

    Department of Chemistry, University of Minnesota (USA)

*Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414 (USA)

  1. †

    We thank X. Gu for help in obtaining spectral data. C.M.S. was supported by NIH Training Grant T32 GM008545 and K.K. by a Royal Thai Government Fellowship; T.H. was the recipient of a Postdoctoral Fellowship from the German Academic Exchange Services. Support from the University of Minnesota through the Vince and McKnight Endowed Chairs is also acknowledged.

Publication History

  1. Issue published online: 12 AUG 2011
  2. Article first published online: 29 JUN 2011
  3. Manuscript Received: 4 MAY 2011

Funded by

  • NIH. Grant Number: T32 GM008545

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Keywords:

  • Kupfervermittelte Reaktionen;
  • Makrocyclisierungen;
  • Naturstoffe;
  • Totalsynthesen;
  • Tumortherapeutika
Thumbnail image of graphical abstract

Ringelreihen: Eine intramolekulare kupfervermittelte reduktive Castro-Stephens-Reaktion lieferte ein zentrales makrocyclisches Trien-Intermediat für die Totalsynthese von Oximidin II. Die Totalsynthese dieses Naturstoffs wurde abgeschlossen und der Mechanismus der neuartigen Schlüsselreaktion aufgeklärt.

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