Synthesis of Oximidine II by a Copper-Mediated Reductive Ene–Yne Macrocyclization

Authors


  • We thank X. Gu for help in obtaining spectral data. C.M.S. was supported by NIH Training Grant T32 GM008545 and K.K. by a Royal Thai Government Fellowship; T.H. was the recipient of a Postdoctoral Fellowship from the German Academic Exchange Services. Support from the University of Minnesota through the Vince and McKnight Endowed Chairs is also acknowledged.

Abstract

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Ringelreihen: Eine intramolekulare kupfervermittelte reduktive Castro-Stephens-Reaktion lieferte ein zentrales makrocyclisches Trien-Intermediat für die Totalsynthese von Oximidin II. Die Totalsynthese dieses Naturstoffs wurde abgeschlossen und der Mechanismus der neuartigen Schlüsselreaktion aufgeklärt.

Ancillary