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Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus

Authors

  • Dr. Xudong Qu,

    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)
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  • Dr. Chun Lei,

    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)
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  • Prof. Dr. Wen Liu

    Corresponding author
    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)
    • State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)
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  • This work was supported in part by grants from NNSF of China (30900021, 20902102, 20921091, and 20832009), SRF for 39th ROCS-SEM, “973 program” (2010CB833200, and 2012CB721100), CAS (KJCX2-YW-201), and STCSM (09QH1402700). We thank Dr. M. J. Smanski from the University of Wisconsin–Madison for discussion and critical reading.

Abstract

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Alternativer Ansatz: Biosynthesewege und die Produktion dazugehöriger Naturstoffe wurden auf Transkriptionsebene in Streptomyces flaveolus mit einer Transkriptom-Screening-Strategie untersucht (siehe Bild). Der Ansatz ergänzt jüngste Fortschritte in der Genomanalyse und könnte die Entdeckung von Naturstoffen aus Bakterienstämmen, deren Genom noch nicht sequenziert wurde, erleichtern.

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