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Diastereoselective Total Synthesis of (±)-Schindilactone A

Authors


  • We are grateful to Prof. Handong Sun for a sample of the natural product schindilactone A, and to Prof. Junmin Quan for his support of computational experiments. This work was supported by grants from the National Basic Research Program (973 Program, Grant 2010CB833201), the National Science and Technology Major Project “Development of Key Technology for the Combinatorial synthesis of Privileged Scaffolds” (2009ZX09501-012), and the National Science Foundation of China (20821062, 20832003 and 20902007).

Abstract

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Eine kurze Route führt zur diastereoselektiven Totalsynthese von (±)-Schindilacton A. Schlüsselschritte sind eine Ringschlussmetathese, eine Thioharnstoff/Cobalt-katalysierte Pauson-Khand-Reaktion und eine Thioharnstoff/Palladium-katalysierte carbonylierende Anellierung. Derivate von Schindilacton A sind ebenfalls zugänglich.

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