This work is granted by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for Next Generation World-Leading Researchers (NEXT Program),” initiated by the Council for Science and Technology Policy (CSTP). Financial support from Tosoh Finechem Corporations, the Noguchi Institute, and a Grant-in-Aid for Scientific Research on Innovative Areas “Integrated Organic Synthesis” is also acknowledged.
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Zuschrift
Tuning Chemoselectivity in Iron-Catalyzed Sonogashira-Type Reactions Using a Bisphosphine Ligand with Peripheral Steric Bulk: Selective Alkynylation of Nonactivated Alkyl Halides†
Article first published online: 1 SEP 2011
DOI: 10.1002/ange.201104125
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hatakeyama, T., Okada, Y., Yoshimoto, Y. and Nakamura, M. (2011), Tuning Chemoselectivity in Iron-Catalyzed Sonogashira-Type Reactions Using a Bisphosphine Ligand with Peripheral Steric Bulk: Selective Alkynylation of Nonactivated Alkyl Halides. Angew. Chem., 123: 11165–11168. doi: 10.1002/ange.201104125
- †
Publication History
- Issue published online: 8 NOV 2011
- Article first published online: 1 SEP 2011
- Manuscript Received: 15 JUN 2011
Funded by
- Japan Society for the Promotion of Science
- JSPS
- Tosoh Finechem Corporations
- Noguchi Institute
- Grant-in-Aid for Scientific Research
Keywords:
- Alkine;
- Eisen;
- Homogene Katalyse;
- Kreuzkupplungen
Sterisch abgeschirmt: Der Eisen-Phosphan-Komplex 1 vermittelt eine hoch C
-selektive Alkinylierung nichtaktivierter Alkylhalogenide mit entsprechenden Grignard-Reagentien. Primäre und sekundäre Alkyliodide, -bromide und -chloride liefern in guten Ausbeuten die substituierten Alkine, die anschließend Cyclisierungen und Kreuzkupplungen eingehen können.