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Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

Authors

  • Hyunjin Kim,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Yoon Kyung Choi,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Jusuk Lee,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Eungyeong Lee,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Jaiwook Park,

    Corresponding author
    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
    • Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Prof. Mahn-Joo Kim

    Corresponding author
    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
    • Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • This work was supported by the National Research Foundation of Korea (KRF-2007-511-C00031 and 2009-0074357).

Abstract

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Aktiv durch Umhüllung: Das auf Burkholderia-cepacia-Lipase basierende Titelsystem ist hoch aktiv in der dynamischen kinetischen Racematspaltung (DKR). Seine wichtigsten Eigenschaften sind: die schnellste DKR von 1-Phenylethanol, die hoch enantioselektive DKR einer Vielzahl sekundärer Alkohole (RCH(OH)Ar) und das Schalten der Lipase-DKR-Enantioselektivität durch die Form der aliphatischen Kette (R).

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