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Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

Authors

  • Vikash P. Chauhan,

    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
    2. Harvard School of Engineering and Applied Sciences, Harvard University (USA)
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    • These authors contributed equally to this work.

  • Dr. Zoran Popović,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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    • These authors contributed equally to this work.

  • Dr. Ou Chen,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Jian Cui,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Prof. Dr. Dai Fukumura,

    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
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  • Prof. Dr. Moungi G. Bawendi,

    Corresponding author
    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
    • Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Prof. Dr. Rakesh K. Jain

    Corresponding author
    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
    • Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
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  • We thank Debby Pheasant (BIF Facility, MIT), Julia Kahn (MGH), and Sylvie Roberge (MGH) for technical assistance. This research was supported by the U.S. National Cancer Institute grants R01-CA126642 (R.K.J. and M.G.B.), R01-CA085140, R01-CA115767 (R.K.J.), P01-CA080124 (R.K.J. and D.F.), R01-CA096915 (D.F.); by the U.S. Department of Defense Breast Cancer Research Program Innovator Award W81XWH-10-1-0016 (R.K.J.); by the MIT-Harvard NIH Center for Cancer Nanotechnology Excellence 1U54-CA119349 (M.G.B.); by the MIT DCIF CHE-980806, DBI-9729592; by the ISN W911NF-07-D-0004 (M.G.B); by the NSF-MRSEC program (DMR-0117795) via the use of its shared user facilities.

Abstract

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Formabhängig: Bei fluoreszierenden Quantenpunkt-Nanokügelchen und -stäbchen mit identischen hydrodynamischen Größen und Oberflächeneigenschaften, aber unterschiedlichen Aspektverhältnissen zeigen bei der In-vivo-Echtzeitbildgebung von Brustkrebstumoren die Nanostäbchen eine schnellere Verteilung als Nanokügelchen vergleichbarer Plasmahalbwertszeit.

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