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Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual C[BOND]H Bond Cleavage of an Arene and Acetonitrile

Authors

  • Tao Wu,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 (China)
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  • Xin Mu,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 (China)
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  • Prof. Dr. Guosheng Liu

    Corresponding author
    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 (China)
    • State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 (China)
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  • We are grateful for the financial support from the National Natural Science Foundation of China (20821002, 20872155, 20972175, and 20923005), the National Basic Research Program of China (973-2009CB825300), and the “Hundred Talent Project” of Chinese Academy of Science.

Abstract

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Nicht eine, sondern zwei: Die Titelreaktion verläuft über eine doppelte C-H-Bindungsspaltung in Acetonitril und einem Anilinderivat (siehe Schema). Die Reaktion liefert eine Vielfalt von Cyano-substituierten Indolinonen in ausgezeichneten Ausbeuten. Mechanistische Studien offenbaren eine schnelle Arylierung des Olefins und die geschwindigkeitsbestimmende C-H-Aktivierung des Acetonitrils.

Ancillary