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Mannose-Functionalized Mesoporous Silica Nanoparticles for Efficient Two-Photon Photodynamic Therapy of Solid Tumors

Authors

  • Dr. Magali Gary-Bobo,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Dr. Youssef Mir,

    1. Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex (France)
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  • Dr. Cédric Rouxel,

    1. Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex (France)
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  • Dr. David Brevet,

    1. Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05 (France)
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  • Dr. Ilaria Basile,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Dr. Marie Maynadier,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Ophélie Vaillant,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Dr. Olivier Mongin,

    1. Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex (France)
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  • Dr. Mireille Blanchard-Desce,

    Corresponding author
    1. Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex (France)
    • Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex (France)
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  • Prof. Alain Morère,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Dr. Marcel Garcia,

    Corresponding author
    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
    • Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Faculté de Pharmacie, Avenue Charles Flahault, 34093 Montpellier Cedex 05 (France)
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  • Dr. Jean-Olivier Durand,

    Corresponding author
    1. Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05 (France)
    • Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05 (France)
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  • Dr. Laurence Raehm

    1. Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05 (France)
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  • Financial support by ANR PNANO. (07-102), ARC (no. SFI20101201906), and the nonprofit organization Rétinostop is gratefully acknowledged. Région Bretagne provided a fellowship to C.R., M.M. was supported by Montpellier 2 University, and O.V. was supported by the “Ligue Nationale contre le Cancer”. We thank Emmanuel Schaub, PIXEL platform (Multiphotonic Microscopy Facilities, University of Rennes 1), Michel Gleizes for histogical sample treatments, the Montpellier RIO imaging platform, Fabrice Senger for expert assistance in conducting TPE-PDT experiments, Céline Frochot for 1O2 quantum yield measurements, and R. Freydier and J. L. Seidel for silicon analyses by ICP-MS (“AETE” Analytical Regional Platform Facilities, OREME observatory of Montpellier 2 University).

Abstract

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Bei Zweiphotonenanregung im Nahinfrarot schrumpfen hoch funktionalisierte mesoporöse Siliciumdioxid-Nanopartikel Tumoren beträchtlich, bei Tageslichtbestrahlung sind sie hingegen ungiftig. Die Nanopartikel führten bei In-vivo-Versuchen zur photodynamischen Therapie (PDT) mit Zweiphotonenanregung an athymischen Mäusen mit Fremdtumoren zu einem Rückgang der Tumorgröße um 70 % nach einer einzigen Behandlung.

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