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Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization

Authors

  • Xiaoxue Zheng,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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    • These authors contributed equally to this work.

  • Qing Liu,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
    2. Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, Shanghai 200237 (China)
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    • These authors contributed equally to this work.

  • Chao Jing,

    1. Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, Shanghai 200237 (China)
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  • Prof. Yang Li,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
    2. Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, Shanghai 200237 (China)
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  • Prof. Di Li,

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • Weijie Luo,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • Yanqin Wen,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • Dr. Yao He,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • Prof. Qing Huang,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • Prof. Yi-Tao Long,

    1. Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, Shanghai 200237 (China)
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  • Prof. Chunhai Fan

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (China)
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  • This work was supported by the National Basic Research Program of China (973 program, 2012CB932600, 2007CB936000), the National Natural Science Foundation of China (20805055, 20873175, 21105028, 21075128, and 20725516), and 2007AA06A406, the Shanghai Municipal Commission for Science and Technology (10A1408200), and the Chinese Academy of Sciences (KJCX2-EW-N03).

Abstract

original image

Durch DNA-Hybridisierung kann dank des deutlichen Unterschieds in der Adsorption einzel- und doppelsträngiger DNA auf der Oberfläche von Au-Nanopartikeln (AuNPs) deren intrinsische Glucoseoxidase-artige katalytische Aktivität reguliert werden. Eine Sensorstrategie für DNA und microDNA wurde entwickelt, und außerdem wurde diese DNA-regulierte AuNP-Katalyse mit AuNP-vermitteltem Kristallwachstum gekoppelt, das in Echtzeit auf Einzelpartikelniveau verfolgt wurde.

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