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Catalytic Asymmetric Activation of a Cmath image[BOND]H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives

Authors

  • Dr. Gen Zhang,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
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  • Yaohu Zhang,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
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  • Prof. Dr. Rui Wang

    Corresponding author
    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
    2. State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong (China)
    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
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  • We are grateful for the grants from the NSFC (20932003 and 90813012) and the Key National S & T Project “Major New Drug Development” of the Ministry of Science and Technology (2009ZX09503-017).

Abstract

original image

Einfach und effizient: Eine oxidative und katalytische enantioselektive Eintopf-Alkylierung von α-Cmath image-H-Bindungen in Nachbarschaft zu einem Stickstoffzentrum wurde erstmals realisiert. Die neuartige Strategie bietet einen einfachen, effizienten und umweltschonenden Zugang zu diversen optisch aktiven α-Alkyl-α-aminosäuren und C1-alkylierten Tetrahydroisochinolinderivaten.

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