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Polyvalent Immunostimulatory Nanoagents with Self-Assembled CpG Oligonucleotide-Conjugated Gold Nanoparticles

Authors

  • Min Wei,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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    • These authors contributed equally to this work.

  • Dr. Nan Chen,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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    • These authors contributed equally to this work.

  • Dr. Jiang Li,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • Min Yin,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • Le Liang,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • Prof. Yao He,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • Prof. Haiyun Song,

    1. Laboratory of Systems Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China)
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  • Prof. Chunhai Fan,

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • Prof. Qing Huang

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)
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  • This work was supported by the National Natural Science Foundation of China (20725516, 10905086, 10975179, 10905087, 90913014, 31100716, and 61008056), the Shanghai Municipal Natural Science Foundation (11ZR1445300), and CAS (KJCX2-EW-N03 and the innovation program). CpG=cytosine–phosphate–guanosine.

Abstract

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Transportvehikel: Gold-Nanopartikel (AuNPs) werden als Träger für die nichtinvasive Einschleusung von synthetischen Cytosinphosphatguanosin(CpG)-Oligodesoxynucleotiden (ODNs) in Zellen genutzt. Verglichen mit nichtkonjugierten einsträngigen CpG-ODNs erhöhen selbstorganisierte polyvalente CpG-AuNP-Konjugate die Effizienz der Zelleinschleusung und stimulieren die Sekretion von Cytokinen (siehe Bild).

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