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Copper-Catalyzed Aerobic Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides

Authors

  • Chun Zhang,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Zejun Xu,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Liangren Zhang,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Dr. Ning Jiao

    Corresponding author
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    2. State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (China)
    • State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Financial support from Peking University, the National Science Foundation of China (No. 20872003), and the National Basic Research Program of China (973 Program 2009CB825300) are greatly appreciated. We thank Prof. Jingfen Lu for helpful discussion.

Abstract

original image

Effizient und praktisch: Die Titelreaktion ergibt eine effiziente Route zu α-Ketoamiden, geläufigen Struktureinheiten in einer Reihe biologisch aktiver Verbindungen. N-substituierte Aniline sind geeignete Substrate für diese Umwandlung. Zwei Cmath image-H-, eine Cmath image-H- und eine N-H-Bindung werden bei dieser Reaktion gespalten. Molekularer Sauerstoff (1 atm) fungiert als Oxidationsmittel, und die Reaktion verläuft über Disauerstoffaktivierung.

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