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Asymmetric N[BOND]H Insertion Reaction Cooperatively Catalyzed by Rhodium and Chiral Spiro Phosphoric Acids

Authors

  • Bin Xu,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Prof. Shou-Fei Zhu,

    Corresponding author
    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
    • State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Xiu-Lan Xie,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Jun-Jie Shen,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Prof. Qi-Lin Zhou

    Corresponding author
    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
    • State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • We thank the National Natural Science Foundation of China and the National Basic Research Program of China (2011CB808600), and the “111” project (B06005) of the Ministry of Education of China for financial support.

Abstract

original image

Achirale Dirhodium(II)-Carboxylate und spirocyclische chirale Phosphorsäuren (SPA) kooperieren in hoch enantioselektiven N-H-Insertionen, die hohe Ausbeuten liefern und schon in Gegenwart geringer Katalysatormengen schnell verlaufen (siehe Schema; Boc=tert-Butyloxycarbonyl, TPA=Triphenylacetyl). Ein SPA-vermittelter asymmetrischer Protonentransfer wird als chiralitätsinduzierender Schritt vorgeschlagen.

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