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A Responsive Hidden Toehold To Enable Controllable DNA Strand Displacement Reactions

Authors

  • Yongzheng Xing,

    1. Key Laboratory of Organic Optoelectronics & Molecular, Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
    2. National Center for Nanoscience and Technology, Beijing 100190 (China)
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  • Prof. Dr. Zhongqiang Yang,

    1. Key Laboratory of Organic Optoelectronics & Molecular, Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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  • Prof. Dr. Dongsheng Liu

    Corresponding author
    1. Key Laboratory of Organic Optoelectronics & Molecular, Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
    • Key Laboratory of Organic Optoelectronics & Molecular, Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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  • We thank National Basic Research Program of China (973 program, No. 2007CB935900 & 2011CB935701), the National Natural Science Foundation of China (No. 20725309 & 91027046), and NSFC-DFG joint project TRR61 for financial support.

Abstract

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In der Schleife: Ein versteckter Ansatzpunkt in einer metastabilen DNA-Schleifenstruktur ermöglicht die Regulierung einer Strangverdrängungsreaktion durch ATP-Zugabe. ATP bindet an ein Aptamer, das zum Teil auf der Schleifensequenz liegt (blau und grün in A), und legt so den Einzelstrang mit dem Ansatzpunkt (grün und rot in Q) frei. Durch die Einführung anderer Aptamersequenzen könnte die Regulierung auf andere kleine Moleküle übertragen werden.

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