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A–T Base Pairs are More Stable Than G–C Base Pairs in a Hydrated Ionic Liquid

Authors

  • Dr. Hisae Tateishi-Karimata,

    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8–9–1 Minatojima-minamimachi, Chuo-ku, Kobe 650–0047 (Japan)
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  • Prof. Dr. Naoki Sugimoto

    Corresponding author
    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8–9–1 Minatojima-minamimachi, Chuo-ku, Kobe 650–0047 (Japan)
    2. Faculty of Frontier of Innovative Research in Science and Technology (FIRST), Konan University (Japan)
    • Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8–9–1 Minatojima-minamimachi, Chuo-ku, Kobe 650–0047 (Japan)
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  • This work was partly supported by the Grants-in-Aid for Scientific Research and the “Core research” project (2009–2014) from the Ministry of Education, Culture, Sports, Science and Technology (Japan). We thank Dr. Kyohei Hayashi and Ms. Kayoko Kishi for collecting the UV melting data.

Abstract

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Ein „grünes“ Lösungsmittel: Quantitative thermodynamische Analysen zeigten, dass in der hydratisierten ionischen Flüssigkeit (IL) Cholindihydrogenphosphat A-T-Basenpaare aufgrund spezifischer Wechselwirkungen zwischen den DNA-Basen und den Cholin-Ionen stabiler sind als G-C-Basenpaare.

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