Rhodium-Catalyzed, Highly Enantioselective 1,2-Addition of Aryl Boronic Acids to α-Ketoesters and α-Diketones Using Simple, Chiral Sulfur–Olefin Ligands

Authors

  • Ting-Shun Zhu,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (China)
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  • Shen-Shuang Jin,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (China)
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  • Prof. Dr. Ming-Hua Xu

    Corresponding author
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (China)
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 (China)
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  • Financial support from the National Natural Science Foundation of China (20972172, 21021063), the Chinese Academy of Sciences, SIMM, and the National Science & Technology Major Project is greatfully acknowledged.

Abstract

original image

Einfach, aber gut: Die Titelreaktion wurde durch eine asymmetrische Rhodium-Katalyse mit einem extrem einfach aufgebauten, chiralen N-(Sulfinyl)cinnamylamin-Liganden erreicht. Die Synthese lieferte unter milden Bedingungen eine Vielfalt von tertiären α-Hydroxycarbonyl-Derivaten mit Enantioselektivitäten bis 99 %.

Ancillary