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Palladium-Catalyzed Carbonylative α-Arylation for Accessing 1,3-Diketones

Authors

  • Thomas M. Gøgsig,

    1. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • Dr. Rolf H. Taaning,

    1. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • Dr. Anders T. Lindhardt,

    1. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Troels Skrydstrup

    Corresponding author
    1. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
    • Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • We thank the Danish National Research Foundation, the Lundbeck Foundation, the Carlsberg Foundation, the iNANO and OChem Graduate Schools, and Aarhus University for generous financial support of this work.

Abstract

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Mit einem Hauch CO: Die ersten Pd-katalysierten carbonylierenden α-Arylierungen von einfachen Ketonen mit Kohlenmonoxid zur direkten Synthese von 1,3-Diketonen werden vorgestellt (siehe Schema). Die Methode verwendet nur stöchiometrische Mengen CO und ermöglicht so die Einführung von Kohlenstoffisotopen in die Kernstruktur heterocyclischer Verbindungen.

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