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Atropoisomeric (P,N) Ligands for the Highly Enantioselective Pd-Catalyzed Intramolecular Asymmetric α-Arylation of α-Branched Aldehydes

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  • This work was supported by the State Secretariat for Education and Research, the Swiss National Foundation (project no. 200020_132681). Roche is also acknowledged for support through an unrestricted grant. Prof. J. Lacour (University of Geneva) is warmly thanked for a generous gift of (R)- and (S)-binol. We thank one referee for constructive comments and suggestions.

Abstract

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Drei in einem: Eine kurze Synthese führt zu neuen chiralen P,N-Liganden mit drei unterschiedlichen Chiralitätselementen, die schwierige Pd-katalysierte intramolekulare asymmetrische α-Arylierungen von α-verzweigten Aldehyden mit hohen Enantioselektivitäten ermöglichen (siehe Bild).

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