Target-Cell-Specific Delivery, Imaging, and Detection of Intracellular MicroRNA with a Multifunctional SnO2 Nanoprobe

Authors

  • Dr. Haifeng Dong,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
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  • Prof. Jianping Lei,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
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  • Prof. Huangxian Ju,

    Corresponding author
    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
    • State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
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  • Dr. Feng Zhi,

    1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093 (P.R. China)
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  • Dr. Hua Wang,

    1. School of Chemistry and Environment, Beijing University of Aeronautics & Astronautics, Beijing 100191 (P.R. China)
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  • Dr. Wenjie Guo,

    1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093 (P.R. China)
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  • Zhu Zhu,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China)
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  • Prof. Feng Yan

    Corresponding author
    1. Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009 (P. R. China)
    • Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009 (P. R. China)
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  • We gratefully acknowledge National Basic Research Program (2010CB732400), National Natural Science Foundation of China (21075055, 21135002, 21121091), and Leading Medical Talents Program from Department of Health of Jiangsu Province.

Abstract

original image

Das Ziel im Visier: Eine multifunktionelle Nanosonde wurde entworfen, die die zellspezifische Bildgebung und den In-situ-Nachweis von intrazellulärer miRNA ermöglicht. Die Nanosonde wurde durch Funktionalisierung von SnO2-Nanopartikeln mit Folsäure (FA), einer zellspezifischen Einheit zur Erkennung von auf Krebszellen überexprimierten Folatrezeptoren und einer Gensonde zur Inhibierung oder Erkennung intrazellulärer miRNA-Spiegel konstruiert (siehe Schema).

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