Innenrücktitelbild: Characterization of the Reaction Path and Transition States for RNA Transphosphorylation Models from Theory and Experiment (Angew. Chem. 3/2012)

Authors

  • Dr. Kin-Yiu Wong,

    Corresponding author
    1. BioMaPS Institute for Quantitative Biology, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (USA)
    • BioMaPS Institute for Quantitative Biology, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (USA)
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  • Dr. Hong Gu,

    1. RNA Center and Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 (USA)
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  • Dr. Shuming Zhang,

    1. RNA Center and Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 (USA)
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  • Prof. Joseph A. Piccirilli,

    Corresponding author
    1. Department of Biochemistry and Molecular Biology and Department of Chemistry, University of Chicago, Chicago, Illinois 60637 (USA)
    • Department of Biochemistry and Molecular Biology and Department of Chemistry, University of Chicago, Chicago, Illinois 60637 (USA)
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  • Prof. Michael E. Harris,

    Corresponding author
    1. RNA Center and Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 (USA)
    • RNA Center and Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 (USA)
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  • Prof. Darrin M. York

    Corresponding author
    1. BioMaPS Institute for Quantitative Biology, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (USA)
    • BioMaPS Institute for Quantitative Biology, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 (USA)
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Abstract

original image

Das Verständnis der Mechanismen von RNA-Reaktionen ist für Forschungen zum Ursprung des Lebens bis hin zur Biotechnologie von Bedeutung. In der Zuschrift auf S. 671 ff. berichten K.-Y. Wong et al. über theoretische und experimentelle Arbeiten zum kinetischen Isotopeneffekt in Modellen der RNA-spaltenden Umesterung. Der Mechanismus und die Übergangszustände sind bei der nativen Verbindung deutlich anders als bei zwei thiosubstituierten Analoga.

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