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Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

Authors

  • Zhaojun Liu,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • Jie Zhang,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • Shulin Chen,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • Erbo Shi,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • Yuan Xu,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • Prof. Dr. Xiaobing Wan

    Corresponding author
    1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University (China)
    • Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (China)
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  • A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and NSFC (20802047, 21072142).

Abstract

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Radikalpartner: Die hier vorgestellte, durch Bu4NI/tert-Butylhydroperoxid (TBHP) katalysierte Synthese von Amiden durch Kreuzkupplung von Acyl- und Aminylradikalen nutzt eine Kombination aus Aldehyd-C-H-Funktionalisierung und Decarbonylierung von N,N-disubstituierten Formamiden (siehe Schema). Die Kreuzkupplung ist metallfrei, für viele Substrate geeignet, einfach durchzuführen und verläuft auch bei größeren Ansätzen in hoher Ausbeute.

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