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Asymmetric Copper-Catalyzed Addition of Grignard Reagents to Aryl Alkyl Ketones

Authors

  • Ashoka V. R. Madduri,

    1. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands)
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  • Dr. Syuzanna R. Harutyunyan,

    Corresponding author
    1. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands)
    • Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands)
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  • Prof. Adriaan J. Minnaard

    Corresponding author
    1. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands)
    • Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen (The Netherlands)
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  • We thank Dr. B. Pugin (Solvias) for the generous gift of a ligand kit for initial screening.

Abstract

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Zugang zu Alkohol: Ein Kupfer(I)-Katalysator mit chiralem Ferrocenyldiphosphanliganden ermöglicht die 1,2-Addition einfacher Grignard-Reagentien an aromatische Ketone ohne Zugabe eines Additivs. Diese Methode macht chirale tertiäre Alkohole mit hervorragenden Ausbeuten und Enantioselektivitäten zugänglich.

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