Innenrücktitelbild: In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles (Angew. Chem. 13/2012)

Authors

  • Yanmei Yang,

    1. Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371 (Singapore)
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  • Qing Shao,

    1. Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371 (Singapore)
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  • Renren Deng,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Chao Wang,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials, Soochow University (P. R. China)
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  • Xue Teng,

    1. Division of Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University (Singapore)
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  • Kai Cheng,

    1. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University Medical Center (USA)
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  • Prof. Zhen Cheng,

    1. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University Medical Center (USA)
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  • Prof. Ling Huang,

    1. Division of Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University (Singapore)
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  • Prof. Zhuang Liu,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials, Soochow University (P. R. China)
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  • Prof. Xiaogang Liu,

    Corresponding author
    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
    2. Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 3 Research Link, Singapore 117602 (Singapore)
    • Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Prof. Bengang Xing

    Corresponding author
    1. Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371 (Singapore)
    • Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371 (Singapore)
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Abstract

original image

Biokonjugate aus D-Luciferin und aufwärts konvertierenden Nanopartikeln (UCNPs) für Photoaktivierung und Biolumineszenz-Bildgebung werden von X. Liu, B. Xing et al. in der Zuschrift auf S. 3179 ff. beschrieben. Nach der Aufwärtskonvertierung von Nah-IR-Photonen durch die bioverträglichen UCNPs wird das D-Luciferin von deren Oberfläche freigesetzt, was verstärkte Biolumineszenzsignale in vitro und in vivo bei großer Eindringtiefe des Lichts und minimaler Zellschädigung ergibt.

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