We acknowledge the National Natural Science Foundation of China (No. 21021001 and 21172151) and the National Basic Research Program of China (973 Program: No. 2011CB808600) for financial support. We also thank Sichuan University Analytical & Testing Center for NMR analysis.
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Zuschrift
Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N′-Dioxide–Metal Complexes†
Article first published online: 3 FEB 2012
DOI: 10.1002/ange.201109130
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wang, Z., Chen, Z., Bai, S., Li, W., Liu, X., Lin, L. and Feng, X. (2012), Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N′-Dioxide–Metal Complexes. Angew. Chem., 124: 2830–2833. doi: 10.1002/ange.201109130
- †
Publication History
- Issue published online: 7 MAR 2012
- Article first published online: 3 FEB 2012
- Manuscript Received: 24 DEC 2011
Funded by
- National Natural Science Foundation of China. Grant Numbers: 21021001, 21172151
- National Basic Research Program of China. Grant Number: 2011CB808600
Keywords:
- 1,4-Additionen;
- Alkinone;
- Asymmetrische Katalyse;
- Scandium;
- Z-Selektivität
Hoch selektiv: Die Titelreaktion gelingt mit hoher Kontrolle der Enantioselektivität und Geometrie und liefert thermodynamisch instabile (Z)-Enon-Derivate als Hauptprodukte (siehe Schema). Eine große Substratbreite wird toleriert, und optisch aktive Pyrazolone mit vinylsubstituierten quartären Stereozentren werden erhalten.