Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species

Authors

  • Dr. Daniel Globisch,

    1. Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037 (USA)
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  • Dr. Colin A. Lowery,

    1. Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037 (USA)
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  • Dr. Karen C. McCague,

    1. Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037 (USA)
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  • Prof. Kim D. Janda

    Corresponding author
    1. Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037 (USA)
    • Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037 (USA)
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  • This work was supported by The Skaggs Institute for Chemical Biology, the National Institutes of Health (AI077644) and by a postdoctoral fellowship from the German Academic Exchange Service (DAAD) to D.G. We also thank Dr. Laura Pasternack for helpful discussions about the NMR studies.

Abstract

original image

Sprachbegabte Bakterien? Die Kombination aus NMR-Spektroskopie und 4,5-Dihydroxy-2,3-pentandion(DPD)-Homologenanalyse belegt, dass die Molekülstruktur von DPD, einem bakteriellen Signalstoff der Autoinducer-2(AI-2)-Klasse (siehe Schema), über ein komplexes Spektrum variieren kann. Diese Entdeckung deutet darauf hin, dass Bakterien über eine umfangreichere chemische Signalsprache verfügen, als bisher angenommen.

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