Palladium-Catalyzed Direct C[BOND]H Arylation of Enamides with Simple Arenes

Authors

  • Dr. Sreekumar Pankajakshan,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)
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  • Dr. Yun-He Xu,

    1. Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P. R. China)
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  • Jun Kee Cheng,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)
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  • Man Ting Low,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)
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  • Prof. Dr. Teck-Peng Loh

    Corresponding author
    1. Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P. R. China)
    2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)
    • Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P. R. China)
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  • We gratefully acknowledge Nanyang Technological University and the Singapore Ministry of Education Academic Research Fund (MOE2011-T2-1-013) for the funding support for this research. We thank Prof. S. Chiba for the helpful discussions.

Abstract

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Nur Z: Eine atomökonomische Synthese von arylierten Z-Enamiden durch doppelte C-H-Funktionalisierung wird beschrieben. Die Z/E-Selektivität der palladiumkatalysierten Monoarylierung ist absolut (Schritt A im Schema), und komplexere Produkte können mithilfe einer anschließenden zweiten Arylierung erhalten werden, die den Einsatz von Trifluoressigsäure (TFA, Schritt B) erfordert.

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