Get access

Surface-Engineered Polyelectrolyte Multilayer Capsules: Synthetic Vaccines Mimicking Microbial Structure and Function

Authors

  • Dr. Bruno G. De Geest,

    Corresponding author
    1. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University (Belgium)
    • Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University (Belgium)
    Search for more papers by this author
  • Monique A. Willart,

    1. VIB Department for Molecular Biomedical Research (Belgium) and Laboratory of Mucosal Immunology and Immunoregulation, Ghent University (Belgium)
    Search for more papers by this author
  • Prof. Dr. Bart N. Lambrecht,

    1. VIB Department for Molecular Biomedical Research (Belgium) and Laboratory of Mucosal Immunology and Immunoregulation, Ghent University (Belgium)
    Search for more papers by this author
  • Charlotte Pollard,

    1. Laboratory of Molecular Immunology, Department of Molecular Biomedical Biology, Ghent University (Belgium)
    2. Institute of Tropical Medicine of Antwerp, Department of Microbiology, Unit Virology, Antwerp (Belgium)
    Search for more papers by this author
  • Prof. Dr. Chris Vervaet,

    1. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University (Belgium)
    Search for more papers by this author
  • Prof. Dr. Jean Paul Remon,

    1. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University (Belgium)
    Search for more papers by this author
  • Prof. Dr. Johan Grooten,

    1. Laboratory of Molecular Immunology, Department of Molecular Biomedical Biology, Ghent University (Belgium)
    Search for more papers by this author
  • Dr. Stefaan De Koker

    1. Laboratory of Molecular Immunology, Department of Molecular Biomedical Biology, Ghent University (Belgium)
    Search for more papers by this author

  • B.G.D.G. acknowledges the FWO Flanders and Ghent University (BOF) for funding. S.D.K. acknowledges Ghent University (BOF) for a postdoctoral scholarship. C.P acknowledges the ITG (SOFI) for a PhD scholarship.

Abstract

original image

Immunisierend: Hohle Kapseln, die aus Schichten von Dextransulfat und Poly-L-arginin bestehen und das Antigen Ovalbumin (orangefarbene Kreise) enthalten, wurden mit immunaktivierenden Oligonukleotiden (grün) funktionalisiert, die CpG-Motive enthalten, um eine hochwirksame Immunantwort gegen rekombinante Antigene hervorzurufen. Die Kapseln wurden in dendritische Zellen aufgenommen (siehe Bild) und wirkten in weiteren Experimenten immunaktivierend.

Get access to the full text of this article

Ancillary