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Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

Authors

  • Zhengbiao He,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
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  • Tao Luo,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
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  • Mingyou Hu,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
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  • Yanjing Cao,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
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  • Prof. Dr. Jinbo Hu

    Corresponding author
    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
    • Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 (China)
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  • Support of our work by the National Natural Science Foundation of China (20825209, 20832008) and the National Basic Research Program of China (2012CB215500) is gratefully acknowledged.

Abstract

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Doppelfunktion: Die Lewis-Säure CuF2⋅2 H2O katalysiert effizient die Umsetzung von α,β-ungesättigten Carbonsäuren mit elektrophilen Fluoralkylierungsreagentien, die Di- und Trifluormethylalkene in hohen Ausbeuten und mit ausgezeichneter E/Z-Selektivität liefert. Das Kupfersalz aktiviert dabei beide Reaktanten.

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